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KMID : 0374019830060010017
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Ewha Medical Journal
1983 Volume.6 No. 1 p.17 ~ p.22
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Studies on the Effect of CCI₄, Phenobarbital and Artemisia Messes-schmidiana Var Viridis on the Biliary Excretion in Rat
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Abstract
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After animals were treated with CC14, histological. changes were shown in the endoplasmic reticul um, and also microsomal activity was decreased and hepatic necrosis, lipid peroxidation in the liver were repoted.
Repeated administration of phenobarbital results in the induction of enzyme that metabolize a number of drugs and, Roberts and Plaa reported that bilirubin
I output was increased significantly after administration of phenobarbital in rats.
Artemisia. was used as folk medicine for the treatment of hyperbilirubinemia. Kiku Tanni(1968) claimed that administration of Artemisia. in patient with acute hepatitis, significantly lowered the bilirubin index, S. G. O. T and S. G. P.T..
} The purpose of the this report was to study the effect of CC141 phenobarbital. Artemisia. on biliary excretion.
The results obtained are summarized as follows.
1) Volume of the bile juice was decreased in CC14 group but increased in phenobarbital and Artemisia. group.
2) Biliary output was slightly decreased in CC14 group but increased in phenobarbital group.
3). Cholate output was decreased in ´ CCI, group, but phenobarbital and Artemisia. group_ was shown sighificant ´increase.
4) Cholesterol output was decreased in CC14 group, but increased in phenobarbital group.
By the above results, it is felt that after treated with phenobarbital and Artemi-
sia. ;following liver damage with CC14 , detoaieation process was shown and the liver damage were protected.
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